期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 85, 期 4, 页码 901-907出版社
SPRINGER
DOI: 10.1007/s00253-009-2306-z
关键词
Entomopathogenic fungi; Metarhizium anisopliae; Beauveria bassiana; Virulence gene; Genetic engineering
资金
- National Basic Research Programof China [2009CB118904]
- Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-YW-G-037]
- National Science foundation
- United States Department of agriculture
- Division Of Integrative Organismal Sys [0965121] Funding Source: National Science Foundation
Molecular biology methods have elucidated pathogenic processes in several fungal biocontrol agents including two of the most commonly applied entomopathogenic fungi, Metarhizium anisopliae and Beauveria bassiana. In this review, we describe how a combination of molecular techniques has: (1) identified and characterized genes involved in infection; (2) manipulated the genes of the pathogen to improve biocontrol performance; and (3) allowed expression of a neurotoxin from the scorpion Androctonus australis. The complete sequencing of four exemplar species of entomopathogenic fungi including B. bassiana and M. anisopliae will be completed in 2010. Coverage of these genomes will help determine the identity, origin, and evolution of traits needed for diverse lifestyles and host switching. Such knowledge combined with the precision and malleability of molecular techniques will allow design of multiple pathogens with different strategies to be used for different ecosystems and avoid the possibility of the host developing resistance.
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