期刊
TETRAHEDRON LETTERS
卷 46, 期 11, 页码 1901-1903出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.01.087
关键词
Biginelli reaction; biphasic media; dihydropyrimidinones; p-TSA as catalyst
An important stage in process development is kilo scale preparation of the target compound. For this reason, a procedure involving water-based biphasic reaction media has been developed for conducting some exothermic reactions on a large scale. This protocol is illustrated by the energy-efficient and rapid preparation of dihydropyrimidinones by a solvent-free, green chemistry procedure applied to the Biginelli reaction using p-toluenesulfonic acid as catalyst. (C) 2005 Published by Elsevier Ltd.
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