期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 15, 期 6, 页码 1553-1556出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.01.076
关键词
hepatitis C virus; RNA polymerase; pyrrolidine; combinatorial mixture
HTS of the compound collection for inhibition of the HCV RNA dependent RNA polymerase identified two 168 member N-acyl pyrrolidine combinatorial mixture hits. Deconvolution and expansion of these mixtures by solid phase synthesis to establish initial SAR and identify a potent inhibitor is reported. (c) 2005 Elsevier Ltd. All rights reserved.
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