期刊
BIOLOGICAL PSYCHIATRY
卷 57, 期 6, 页码 624-632出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2004.12.038
关键词
amygdala; striatum; emotion regulation; go/nogo; fMRI
资金
- NIDA NIH HHS [R01 DA18879, R21 DA15882] Funding Source: Medline
- NIMH NIH HHS [R01 MH091864] Funding Source: Medline
Background: Emotional information can facilitate or interfere with cognitive processes. In this study, we examined the influence of emotional. information in biasing performance and the biological basis underlying this influence. Methods: Ten human subjects (five female) were scanned with functional magnetic resonance imaging while performing an emotional go/nogo, task. Results: Subjects were slower to approach fearful target expressions and had more difficulty avoiding happy nontarget expressions. The amygdala was recruited most for negative emotional context, and activity in this region was positively correlated with response time when detecting negative expressions. Increased signal in the right caudate nucleus was observed when avoiding nontargets and was negatively correlated with the number of false alarms subjects made. Conclusions: Emotional context can alter behavioral and biological responses when approaching or avoiding a stimulus. We showed that recruitment of the amygdala, a region implicated in evaluating emotional significance, was associated with longer response latencies when approaching negative information, whereas recruitment of the caudate nucleus, a structure previously implicated in reward and impulse control, was most active when avoiding positive information. Our findings have significant implications for exaggerated and inhibited emotional responses that are characteristic of a number of psychiatric disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据