期刊
FEMS MICROBIOLOGY LETTERS
卷 244, 期 2, 页码 359-365出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.femsle.2005.02.015
关键词
mucosal candidiasis; colonization; virulence factor; animal model
类别
资金
- NIDCR NIH HHS [DE-13968] Funding Source: Medline
The human pathogenic fungus Candida albicans, which can reside as a benign commensal of the gut, possesses a large family of lipase encoding genes whose extracellular activity may be important for colonization and subsequent infection. The expression of the C albicans lipase gene family (LIP1-10) was investigated using a mouse model of mucosal candidiasis during alimentary tract colonization (cecum contents) and orogastric infection. LIPs4-8 were expressed in nearly every sample prepared from the cecum contents and infected mucosal tissues (stomach, hard palate, esophagus and tongue) suggesting a maintenance function for these gene products. In contrast, LIPs1, 3, and 9, which were detected consistently in infected gastric tissues, were essentially undetectable in infected oral tissues. In addition, LIP2 was expressed consistently in cecum contents but was undetectable in infected oral tissues suggesting LIP2 may be important for alimentary tract colonization, but not oral infection. The host responded to a C albicans infection by significantly increasing expression of the chemokines MIP-2 and KC at the site of infection. Therefore, differential LIP gene expression was observed during colonization, infection and at different infected mucosal sites. (c) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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