期刊
OPTICS LETTERS
卷 30, 期 6, 页码 625-627出版社
OPTICAL SOC AMER
DOI: 10.1364/OL.30.000625
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资金
- NIBIB NIH HHS [R01 EB000712] Funding Source: Medline
- NINDS NIH HHS [R01 NS046214, R01 NS46214] Funding Source: Medline
Reflection-mode photoacoustic microscopy with dark-field laser pulse illumination and high-numerical-aperture ultrasonic detection is designed and implemented in noninvasively imaged blood vessels in the skin in viuo. Dark-field optical illumination minimizes the interference caused by strong photoacoustic signals from superficial structures. A high-numerical-aperture acoustic lens provides high lateral resolution, 45-120 mum in this system. A broadband ultrasonic detection system provides high axial resolution, estimated to be similar to15 mum. The optical illumination and ultrasonic detection are in a coaxial confocal configuration for optimal image quality. The system is capable of imaging optical-absorption contrast as deep as 3 mm in biological tissue. (C) 2005 Optical Society of America.
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