期刊
DEVELOPMENTAL BIOLOGY
卷 279, 期 2, 页码 481-490出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2004.12.019
关键词
Sox9; Nkx2.5; BMP signaling; pyloric sphincter; epithelial-mesenchymal interactions
资金
- NCRR NIH HHS [P20 RR-016463] Funding Source: Medline
- NHLBI NIH HHS [HL56585] Funding Source: Medline
The organs of the digestive tract are specified by coordinated signaling between the endoderm and mesoderm during development. These epithelial-mesenchymal interactions lead to the organ-specific morphogenesis and differentiation of regions along the gut tube. In this paper, we show that in the chick, the SRY-related transcription factor Sox9 is a marker for the posterior gizzard. Viral misexpression of Sox9 in the gizzard mesoderm is sufficient to specify epithelium characteristic of the pyloric sphincter. Sox9 expression is normally limited to the region of the posterior gizzard under the regulation of BMP signaling from the adjacent midgut. Misexpression of an activated form of BMPR1b in the gizzard upregulates Sox9 expression, while the BMP antagonist noggin down-regulates Sox9 expression in the gizzard mesoderm. previously, Nkx2.5 was identified as a marker for the mesoderm of the pyloric sphincter. As with Sox9, BMP signaling appears to regulate Nkv2.5 and its ability to determine the pyloric epithelium. Despite these similarities, our evidence suggests that Sox9 and Nkx2.5 are regulated independently by BIMP signaling, and act coordinately to specify the pyloric sphincter. (C) 2004 Elsevier Inc. All rights reserved.
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