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Synthesis of pelorol and analogues: Activators of the inositol 5-phosphatase SHIP

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卷 7, 期 6, 页码 1073-1076

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AMER CHEMICAL SOC
DOI: 10.1021/ol047316m

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A screening program designed to find new antiinflammatory agents has identified the sponge meroterpenoid pelorol (1) as an in vitro activator of the inositol-5-phosphatase SHIP. Pelorol (1) and several functional group analogues have been synthesized from sclareolide (4).

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