期刊
CANCER LETTERS
卷 220, 期 1, 页码 85-93出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2004.07.044
关键词
DNA mismatch repair; colon carcinoma; DNA polymerase; DNA replication; hypersensitive
类别
We studied the cytotoxic effects of various DNA replication inhibitors on MMR-deficient and -proficient colon carcinoma cell lines. DNA polymerase (pol) inhibitors including aphidicolin and gemcitabine, and hydroxyurea were more toxic (1.7 to 2.8-fold) to hMLH1-deficient HCT116 than to hMLH1-proficient HCT116+ch3. Similarly, pol inhibitors were more toxic to hMSH2-deficient LoVo than to hMSH2-proficient LoVo + ch2. In contrast, DNA topoisomerase I inhibitors, such as CPT-11, SN-38, and topotecan, were more toxic to MMR-proficient cells. Our results suggest that NINIR-deficient colon carcinoma cells are hypersensitive to inhibitors of the pol reaction. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
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