期刊
JOURNAL OF CONTROLLED RELEASE
卷 103, 期 2, 页码 291-299出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2004.11.035
关键词
percutaneous absorption; transepidermal water loss; skin permeability and toxicity
Independently, both transepidermal water loss (TEWL) and percutaneous absorption measurements accurately gauge stratum corneum skin water barrier integrity. Both TEWL and percutaneous absorption rates increase when the integrity of the SC barrier is compromised. Experiments to discern a quantitative and/or qualitative correlation between the two indicators have resulted in controversy. This paper reviews some major studies investigating this correlation. (c) 2005 Elsevier B.V. All rights reserved.
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