期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 102, 期 12, 页码 4512-4517出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0408773102
关键词
acute infection; correlate of protection; multiparameter flow cytometry
资金
- Medical Research Council [G108/441] Funding Source: Medline
- NIAID NIH HHS [5T32 AI07392, R01-AI49126, U01-AI41530, 3P30-AI28662, T32 AI007392, R01 AI050483, 5U01-AI46725, U01 AI046725, U01 AI041530, R01 AI049126, 5R01-AI50483] Funding Source: Medline
- Medical Research Council [G108/441] Funding Source: researchfish
- MRC [G108/441] Funding Source: UKRI
Worldwide HIV-1 vaccine efforts are guided by the principle that HIV-specific T cell responses may provide protection from infection or delay overt disease. However, no clear correlates of T cell-mediated immune protection have been identified. Here, we examine in a HLA-B27(+) HIV seronegative vaccinee persistent HIVspecific vaccine-induced anti-Gag CD4(+) and CD8(+) T cell responses. Although these responses exhibited those characteristics (multi-functionality, appropriate memory phenotype, and targeting of epitopes associated with long-term nonprogression) predicted to correlate with protection from infection, the subject became HIV infected. After HIV infection, the vaccine-induced CD8(+) T cells expanded, but both CD4(+) and CD8(+) T cell responses acquired the functional and phenotypic patterns characteristic of chronic HIV infection. The virus quickly escaped the vaccine-induced T cell response, and the subject progressed more rapidly than expected for someone expressing the HLA-B27 allele. These data suggest that control of HIV by vaccine-elicited HIV-specific T cell responses may be difficult, even when the T cell response has those characteristics predicted to provide optimal protection.
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