期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 328, 期 4, 页码 1133-1138出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2005.01.070
关键词
cytoskeleton; microfilaments; microtubules; intermediate filaments; mechanotransduction
资金
- NHLBI NIH HHS [HL-33009] Funding Source: Medline
A fundamental question in the field of mechanotransduction is how forces propagate inside a cell. Recent experiments have shown that a force of a physiological magnitude, applied via a focal adhesion, can propagate a long distance into the cell. This observation disagrees with existing models that regard the cell as a homogeneous body. We show that this action at a distance results from the inhomogeneity in the cell: a prestressed and stiff actin bundle guicics the propagation of forces over long distances. Our models highlight the enormous ratios of the prestress and the modulus of the actin bundle to the modulus of the cytoskeleton network. For a normal cell, the models predict that forces propagate over characteristic lengths comparable to the size of the cell. The characteristic lengths can be altered, however, by treatments of the cell. We provide experimental evidence and discuss biological implications. (C) 2005 Elsevier Inc. All rights reserved.
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