期刊
BRAIN RESEARCH
卷 1039, 期 1-2, 页码 220-223出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2005.01.061
关键词
cerebral ischemia; histamine; histidine; H-2 receptors; middle cerebral artery; rats
Focal cerebral ischemia for 2 h by occlusion of the right middle cerebral artery provoked severe brain infarction in the rat brain after 24 h. Intraperitoneal administration of histidine, a precursor of histamine, immediately and 6 h after reperfusion, alleviated brain infarction. The infarct size in the histidine (200 mg/kg, 500 mg/kg, and 1000 mg/kg, each time) groups was 71%, 39%, and 7% of that in the control group, respectively. Although intracerebroventricular administration of mepyramine (3 nmol), an H-1 antagonist, did not affect the morphologic outcome in histidine-treated rats, ranitidine (30 nmol), an H-2 antagonist, completely abolished the alleviation caused by histidine. These findings indicate that postischemic administration of histidine prevents development of brain infarction by stimulating central histamine H-2 receptors. (c) 2005 Elsevier B.V. All rights reserved.
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