期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 360, 期 1455, 页码 483-496出版社
ROYAL SOC
DOI: 10.1098/rstb.2004.1604
关键词
sister chromatid cohesion; cohesin; SMC and Kleisin proteins; chromosome segregation; mitosis; meiosis
类别
The sister chromatid cohesion essential for the bi-orientation of chromosomes on mitotic spindles depends on a multi-subunit complex called cohesin. This paper reviews the evidence that cohesin is directly responsible for holding sister DNAs together and considers how it might perform this function in the light of recent data on its structure.
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