期刊
JOURNAL OF NEUROSCIENCE
卷 25, 期 13, 页码 3280-3286出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3420-04.2005
关键词
learning; memory; fMRI; CA3; subiculum; recollection
资金
- NHLBI NIH HHS [441587-HB-33589] Funding Source: Medline
The hippocampal formation performs two related but distinct memory functions: encoding of novel information and retrieval of episodes. Little evidence, however, resolves how these two processes are implemented within the same anatomical structure. Here we use high-resolution functional magnetic resonance imaging to show that distinct subregions of the hippocampus are differentially involved in encoding and retrieval. We found that regions early in the hippocampal circuit (dentate gyrus and CA fields 2 and 3) were selectively active during episodic memory formation, whereas a region later in the circuit (the subiculum) was active during the recollection of the learning episode. Different components of the hippocampal circuit likely contribute to different degrees to the two basic memory functions.
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