期刊
ORGANIC LETTERS
卷 7, 期 7, 页码 1387-1390出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol050203y
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资金
- NIGMS NIH HHS [R01 GM071779] Funding Source: Medline
A phosphine-catalyzed reaction of an allenoate with aldehydes furnished (2,6-diaryl-[1,3]dioxan-4-ylidene)-acetates 4 in excellent to moderate yields with complete diastereoselectivity and high E/Z-selectivities. Upon removal of the acetal functionality in this domino reaction product 4, delta-hydroxy-beta-ketoester 11 was obtained. The reported vinylphosphonium-based approach provides a new way to achieve a synthesis of 6-hydroxy-beta-ketoesters that differs from the classical dianion-based approach.
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