期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 40, 期 4, 页码 401-405出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2004.12.001
关键词
pyrazole; antimicrobial activity; pyrazolo-pyridazin
Several new pyrazolo[3,4-d]pyridazin derivatives were prepared by the reaction of two new 1H-pyrazole-3-carboxylic acids and various hydrazines. The compounds were tested for antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi. The compounds named as 7e, f had the highest antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi with minimum inhibitory concentrations in the range of 0.31 to < 0.0024 mg ml(-1). (c) 2005 Elsevier SAS. All rights reserved.
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