期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 53, 期 4, 页码 378-381出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.53.378
关键词
Lamiaceae; Otostegia limbata; clerodane diterpenoid; cholinesterase inhibitory assay
Three new tricyclic cis-clerodane type diterpenoids trivially named as limbatolide A (1), limbatolide B (2) and limbatolide C (3) have been isolated from the roots of Otostegia limbata along with two known compounds; oleanic acid and beta-sitosterol. The structure elucidation of the new compounds was based primarily on two-dimensional (2D) NMR techniques. Compounds 1-3 displayed inhibitory potential in a concentration-dependent manner against acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8) enzymes, respectively.
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