期刊
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
卷 38, 期 4, 页码 500-503出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.qai.0000138160.91568.19
关键词
antiretroviral therapy; cohort studies; discontinuation; HIV/AIDS
资金
- NCRR NIH HHS [M01-RR00083, M01-RR00079] Funding Source: Medline
- NIAID NIH HHS [U01-AI-34989, U01-AI-35004, U01-AI-34994, U01-AI-42590, U01-AI-31834, U01-AI-34993] Funding Source: Medline
- NICHD NIH HHS [U01-HD-32632] Funding Source: Medline
We characterized factors and temporal trends associated with discontinuation of highly active antiretroviral therapy (HAART) among 936 HIV-infected women enrolled in the Women's Interagency HIV Study. A multivariate analysis of post-HAART initiation exposures found that high HIV RNA levels (relative hazard [RH] = 1.36, P < 0.001) and high depressive symptom scores (RH = 1.53, P = 0.012) were associated with HAART discontinuation. The adjusted hazard of discontinuation was higher in the 2 most recent calendar periods compared with the first (RH = 1.61, P = 0.026; RH = 1.56, P = 0.074, respectively). The increasing risk of HAART discontinuation in recent calendar periods and changes in the clinical factors associated with discontinuation reflect ongoing and dynamic shifts in the approach to HAART utilization.
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