期刊
SEMINARS IN IMMUNOLOGY
卷 17, 期 2, 页码 155-165出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2005.01.001
关键词
microRNAs; RNA interference; Hematopoiesis; B cells; leukemia
类别
资金
- NHLBI NIH HHS [R01 HL081612, R01 HL081612-01, R01 HL081612-02] Funding Source: Medline
- NIDDK NIH HHS [R01 DK068348] Funding Source: Medline
MicroRNAs (miRNAs) are an abundant class of similar to 22 nucleotide non-coding RNAs and play important regulatory roles in animal and plant development at the post-transcriptional level. Many miRNAs cloned from mouse bone marrow cells are differentially regulated in various hematopoietic lineages, suggesting that they might influence hematopoietic lineage differentiation. miR-181, a miRNA specifically expressed in B cells within mouse bone marrow, promotes B-cell differentiation when expressed in hematopoietic stem/progenitor cells. Some human miRNAs are linked to leukemias: the miR-15a/miR-16 locus is frequently deleted or down-regulated in patients with B-cell chronic lymphocytic leukemia and miR-142 is at a translocation site found in a case of aggressive B-cell leukemia. Collectively, these results indicate that miRNAs may be important regulators of mammalian hematopoiesis. Here, we provide background on the biogenesis and function of miRNAs and discuss how miRNA-mediated post-transcriptional regulation may influence the development and function of blood cells. (c) 2005 Elsevier Ltd. All rights reserved.
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