Decrease of serotonin transporters in blood platelets after epileptic seizures

Serotonin transporter (SERT) was studied by [H-3]-paroxetine binding in blood platelets from controls and epileptic patients with generalized convulsive seizures. The average K-D and B-Max were not different in the two cases. However, a significant decrease was found in the serotonin transporter density in the platelet membranes from patients having undergone an epileptic seizure less than 4 days before. This circumstance may indicate a homeostatic reaction to the epileptic attack.