期刊
ARCHIV DER PHARMAZIE
卷 338, 期 4, 页码 175-180出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.200400953
关键词
synthesis; antioxidants; fused pyridine analogs
A new series of pyrano[3,2-c]pyridines, pyrazolo[4,3-c]pyridines, and pyrido[4,3-d]pyrimidines were synthesized and screened for their in vitro antioxidant activity. Compounds 13, 14, 15, 23, 29, 30, and 31 exhibited the most active oxygen free-radical scavenger activity with percentage inhibitions of 99.4, 99.6, 99.8, 97.3, 99.0, 99.3, and 99.55: respectively, which is comparable to the curcumin potency. Most of the tested compounds proved to be safe towards peripheral multinuclear neutrophils (PMNs). The detailed synthesis and antioxidant activity data are reported.
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