期刊
BRAIN RESEARCH REVIEWS
卷 48, 期 2, 页码 133-143出版社
ELSEVIER
DOI: 10.1016/j.brainresrev.2004.12.003
关键词
microglia; receptors; ion channels; calcium; patch clamp
Microglial cells in culture and in situ express a defined pattern of K+ channels, which is distinct from that of other glial cells and neurons. This pattern undergoes defined changes with microglial activation. As expected for a cell with immunological properties, microglia express a variety of cytokine and chemokine receptors, which are linked to the mobilization of Ca2+ (cytosolic free calcium) from internal stores. Microglial cells also have the capacity to respond to neuronal activity: they express receptors for the major excitatory receptor glutamate and the main inhibitory receptor GABA (gamma-amino butyric acid). By expressing purinergic receptors, rnicroglia can sense astrocyte activity in the form of Ca2+ waves. Activation of transmitter receptors can affect cytokine release which is a potential means as to how brain activity can affect immune function. (c) 2004 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据