期刊
INFECTION AND IMMUNITY
卷 73, 期 4, 页码 2547-2549出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.73.4.2547-2549.2005
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资金
- NIAID NIH HHS [R01 AI039557, R01 AI044486, AI39557, AI44486] Funding Source: Medline
Isocitrate lyase is required for fatty acid utilization via the glyoxylate shunt. Although isocitrate lyase is essential for Salmonella persistence during chronic infection, it is dispensable for acute lethal infection in mice. Substrate availability in the phagosome appears to evolve over time, with increasing fatty acid dependence during chronic infection.
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