期刊
PROTEIN AND PEPTIDE LETTERS
卷 12, 期 3, 页码 245-249出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929866053587200
关键词
high hydrostatic pressure; amyloidogenic diseases; protein folding; protein aggregation; transthyretin
High hydrostatic pressure (HHP) is a powerful tool to study protein folding and the dynamics and structure of folding intermediates. Aggregates and amyloids, derived from partially folding intermediates at the Junction between productive and off-pathway folding, have been studied as well, which promises better understanding of the protein misfolding diseases. Here is summarized the recent data we have collected with transthyretin under pressure.
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