期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 9, 期 2, 页码 97-103出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2005.02.005
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资金
- NIEHS NIH HHS [5 R01 ES012236-02] Funding Source: Medline
De novo design of metalloproteins provides a valuable tool for understanding the structural constraints and functional attributes of natural biological systems using first principles. This review focuses on recent research aimed primarily at probing the subtle interactions between metals and proteins in designed systems. Considerable attention has focussed on redefining novel design methods used in mimicking natural hemeproteins, mononuclear and dinuclear metallopeptides and functional biological electron-transfer proteins. The present results indicate that the field of metalloprotein design is contributing significantly to the understanding of metals in biology.
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