期刊
CLINICAL GENETICS
卷 67, 期 4, 页码 290-296出版社
WILEY
DOI: 10.1111/j.1399-0004.2005.00418.x
关键词
congenital malformations; Dandy-Walker; development; heterotaxy; holoprosencephaly; neural tube defects; ZIC
The human ZIC gene family is comprised of five members encoding zinc-finger transcription factors, which are the vertebrate homologs of the Drosophila odd-paired gene. Mutations in ZIC genes in humans have recently been implicated in a wide variety of congenital malformations, including Dandy-Walker malformation, holoprosencephaly, neural tube defects, and heterotaxy. Mutant analysis of these genes in mice has underscored the conserved developmental roles of these genes. Further, this analysis has begun to elucidate the molecular and developmental mechanisms underlying these important birth defects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据