期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 16, 期 2, 页码 215-224出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2004.12.002
关键词
apoptosis; programmed cell death; cell cycle; checkpoints; development
Apoptosis is a mechanism employed by multicellular organisms throughout development as a means of eliminating damaged or otherwise unwanted cells. From oogenesis through fertilization and gastrulation, organisms use an array of cell- and tissue-specific mechanisms to regulate the apoptotic program in response to stress or developmental cues. Since cell death regulation is tightly interwoven with cell cycle and checkpoint controls, and embryos of the fly, fish and frog exhibit unique embryonic cell cycle regulation, it is of great interest to understand how early embryos coordinate these cellular functions. (c) 2004 Elsevier Ltd. All rights reserved.
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