期刊
BIOCHEMICAL GENETICS
卷 43, 期 3-4, 页码 175-187出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10528-005-1510-5
关键词
glucose transporter; distribution in brain; expression in brain disease; neuroactive drug; saccharide; blood-brain barrier
Facilitative glucose transport is mediated by one or more of the members of the closely related glucose transporter ( GLUT) family. Thirteen members of the GLUT family have been described thus far. GLUT1 is a widely expressed isoform that provides many cells with their basic glucose requirement. It is also the primary transporter across the blood-brain barrier. This review describes the distribution and expression of GLUT1 in brain in different pathophysiological conditions including Alzheimer's disease, epilepsy, ischemia, or traumatic brain injury. Recent investigations show that GLUT1 mediates the transport of some neuroactive drugs, such as glycosylated neuropeptides, low molecular weight heparin, and D-glucose derivatives, across the blood-brain barrier as a delivery system. By utilizing such highly specific transport mechanisms, it should be possible to establish strategies to regulate the entry of candidate drugs.
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