期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 126, 期 4, 页码 491-504出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2004.10.007
关键词
yeast aging; caloric restriction; genetic pathways
资金
- NIA NIH HHS [P30 AG013280] Funding Source: Medline
Here we describe the replicative life spans of more than 50 congenic Saccharomyces cerevisiae strains, each carrying a mutation previously implicated in yeast aging. This analysis provides a direct comparison, in a single, long-lived strain background, of a majority of reported yeast aging genes. Of the eleven deletion mutations previously reported to increase yeast life span, we find that deletion of FOB1, deletion of SCH9, and deletion of GPA2, GPR1, or HXK2 (three genetic models of calorie restriction) significantly enhanced longevity. In addition, overexpression of SIR2 or growth on low glucose increased life span. These results define a limited number of genes likely to regulate replicative life span in a strain-independent manner, and create a basis for future epistasis analysis to determine genetic pathways of aging. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
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