期刊
MICROCIRCULATION
卷 12, 期 3, 页码 247-258出版社
WILEY
DOI: 10.1080/10739680590925493
关键词
glycoprotein IIb/IIIa receptor; nitric oxide; platelet inhibitors; platelets; S-nitrosothiols
资金
- NHLBI NIH HHS [HL61795, HL55993, HL58976] Funding Source: Medline
Platelets play an important role in coagulation, in maintenance of hemostasis, and in the pathophysiology of thrombotic diseases. In response to blood vessel injury, platelets accumulate at the site, recruit other platelets, promote clotting, and form a hemostatic plug to prevent hemorrhage. By contrast, several inhibitory mechanisms modulate platelet function and act in a synergistic manner to prevent pathologic thrombus formation. This review focuses inhibitors of platelet function and the central role of the normal endothelium in these inhibitory processes. The main endothelium-derived platelet inhibitors include nitric oxide, prostacyclin, and Ecto-ADPase/CD39/NTPDase. Each of these factors is discussed in turn, and the specific mechanisms by which they inhibit platelet function are reviewed.
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