期刊
IMMUNOLOGY
卷 114, 期 4, 页码 493-498出版社
WILEY
DOI: 10.1111/j.1365-2567.2004.02113.x
关键词
T lymphocytes; lipopolysaccharide; complement; cell surface molecules; cellular activation
类别
资金
- NHLBI NIH HHS [HL70729, R01 HL067290, HL67290, R01 HL070729] Funding Source: Medline
- NIAID NIH HHS [R21 AI051835, AI51835] Funding Source: Medline
Complement receptors type 1 and 2 (CR1 (CD35)/CR2 (CD21)) are known to enhance the adaptive immune response. In mice, CR1/CR2 are expressed on B cells, follicular dendritic cells, and activated granulocytes. Recently, we showed that a subset of CD44(high) and CD62L(low) T cells also expresses CR1 and CR2. We now report that CR1/CR2 are detectable on both CD4(+) and CD8(+) subsets of T cells. Lipopolysaccharide (LPS) from Gram-negative bacteria causes polyclonal activation of B cells and stimulation of macrophages and other antigen-presenting cells. We further demonstrate that LPS induced marked up-regulation of CD25 and CD69 on T cells from CR1/CR2 sufficient (Cr+/+), but significantly lower up-regulation on T cells from CR1/CR2 deficient (Cr-/-) mice. These findings point to a novel mechanism by which CR1/CR2 modulates the activation of T cells by LPS.
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