期刊
CURRENT OPINION IN CELL BIOLOGY
卷 17, 期 2, 页码 129-134出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2005.01.003
关键词
-
类别
资金
- Medical Research Council [G8604010] Funding Source: Medline
- MRC [G8604010] Funding Source: UKRI
- Medical Research Council [G8604010] Funding Source: researchfish
Various methods reveal that cyclic AMP (cAMP) signalling in cells is compartmentalised. These methods use FRET probes based upon either protein kinase A (PKA) or EPAC, cAMP-gated ion channels, or the selective activation of AKAP-anchored PKA isoforms. The basis of compartmentalisation involves point sources of cAMP generation within sub-domains of the plasma membrane coupled to degradation by spatially segregated, anchored forms of cAMP phosphodiesterases. cAMP-specific phosphodiesterase-4 (PDE4) isoforms play a central role in determining compartmentalisation, as exemplified in cardiac myocytes; and T cells. The PKA phosphorylation status of the beta(2)-adrenoreceptor, and hence its ability to switch its signalling from G(s) to G(i) and thus to activate ERK, is regulated dynamically by the agonist-stimulated recruitment of PDE4 to the receptor in complex with P-arrestin. The co-receptor CD28 enhances signalling through the T-cell receptor by recruiting a PDE4/beta-arrestin complex, which then attenuates PKA phosphorylation of Csk.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据