期刊
INTERNATIONAL JOURNAL OF STD & AIDS
卷 16, 期 4, 页码 299-301出版社
ROYAL SOC MEDICINE PRESS LTD
DOI: 10.1258/0956462053654302
关键词
syphilis; oral fluid; diagnosis; screening
We have developed a time-resolved fluorescence immunoassay to detect antibodies to Treponema pallidum recombinant antigens in oral fluid specimens. L sing an 'Oracol' swab, oral fluid was collected from 34 subjects with a serological diagnosis of syphilis and 97 seronegative controls. Using a cut-off of three standard deviations over control mean, the sensitivity and specificity of the assay in all subjects with positive syphilis serology was 76.5% and 97.9%, respectively. In those with early syphilis, the sensitivity and specificity of the assay was 100% and 97.9%. lit a non-outbreak situation, screening clinic attendees for syphilis using oral fluid specimens is potentially useful when collection of blood is not practicable. In addition, it may have much to offer in outreach projects and epidemiological investigations.
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