期刊
FERTILITY AND STERILITY
卷 83, 期 -, 页码 1297-1302出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2004.11.040
关键词
endometrium; implantation window; L-selectin ligand; uterine receptivity
Objective: To evaluate the expression of L-selectin ligand in the endometrium during the menstrual cycle. Design: Retrospective study. Setting: University teaching hospital. Patient(s): Endometrial samples from regularly cycling women. Intervention(s): Tissue microarray and immunohistochemical staining were performed using L-selectin ligand monoclonal antibody (MECA-79). Main Outcome Measure(s): Expression of L-selectin ligand in the various phases of menstrual cycle was measured by a semiquantitative analysis (HSCORE) for the intensity of immunohistochemical reactivity. Result(s): In the luminal epithelium, there were significant differences in L-selectin ligand expression during the proliferative, interval, early secretory, and midsecretory phases. The expression of L-selectin ligand was greatest from the periovulatory interval through midsecretory phase. In the glandular epithelium, the expression of L-selectin ligand was greatest in midsecretory phase with significant differences between proliferative phase and the midsecretory phase and between the interval phase and the midsecretory phase. Conclusion(s): Increased expression of L-selectin ligand in the human endometrium during the early and midsecretory phases of the menstrual cycle may be related to the process of implantation. (Fertil Steril((R)) 2005; 83(Suppl 1): 1297-1302. (c) 2005 by American Society for Reproductive Medicine.)
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