期刊
PLOS BIOLOGY
卷 3, 期 4, 页码 588-598出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.0030093
关键词
-
资金
- NIGMS NIH HHS [R01 GM61001, R01 GM061001] Funding Source: Medline
Lack of knowledge about how regulatory regions evolve in relation to their structure-function may limit the utility of comparative sequence analysis in deciphering cis-regulatory sequences. To address this we applied reverse genetics to carry out a functional genetic complementation analysis of a eukaryotic cis-regulatory module-the even-skipped stripe 2 enhancer-from four Drosophila species. The evolution of this enhancer is non-clock-like, with important functional differences between closely related species and functional convergence between distantly related species. Functional divergence is attributable to differences in activation levels rather than spatiotemporal control of gene expression. Our findings have implications for understanding enhancer structure-function, mechanisms of speciation and computational identification of regulatory modules.
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