期刊
JOURNAL OF GENERAL VIROLOGY
卷 86, 期 -, 页码 919-928出版社
MICROBIOLOGY SOC
DOI: 10.1099/vir.0.80661-0
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资金
- MRC [G9800943] Funding Source: UKRI
- Medical Research Council [G9800943] Funding Source: researchfish
- Medical Research Council [G9800943] Funding Source: Medline
Murine gammaherpesvirus-68 (MHV-68) ORF28 is a gammaherpesvirus-specific gene of unknown function. Analysis of epitope-tagged ORF28 protein indicated that it was membrane-associated and incorporated into virions in N-glycosylated, O-glycosylated and unglycosylated forms. The extensive glycosylation of the small ORF28 extracellular domain - most forms of the protein appeared to be mainly carbohydrate by weight - suggested that a major function of ORF28 is to attach a variety of glycans to the virion surface. MHV-68 lacking ORF28 showed normal lytic replication in vitro and in vivo and normal latency establishment. MHV-68 ORF28 therefore encodes a small, membrane-bound and extensively glycosylated virion protein, whose function is entirely dispensable for normal, single-cycle host colonization.
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