期刊
HEARING RESEARCH
卷 202, 期 1-2, 页码 63-73出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.heares.2004.08.011
关键词
mouse; cochlea; place-frequency map; cochlear nucleus; tonotopy
Genetically manipulated mice have gained a prominent role in in vivo research on development and function of the auditory system. A prerequisite for the interpretation of normal and abnormal structural Mid functional features of the inner ear is the exact knowledge of the cochlear place-frequency map. Using a stereotaxic approach to the projection site of the auditory nerve fibers ill the cochlear nucleus. we succeeded in labelling physiologically characterized auditory nerve afferents and determined their peripheral innervation site in the cochlea. From the neuronal characteristic frequency (CF) and the innervation site in the organ of Corti a place-frequency map was established for characteristic frequencies between 7.2 and 61.8 kHz, corresponding to locations between 90% and 10% basilar membrane length (base = 0%, apex = 100%, mean length measured tinder the inner hair cells 5.13 mm). The relation between normalized distance from the base (d) and frequency (kHz) can be described by a simple logarithmic function: d(%) = 156.5 - 82.5 x log(f), With a slope of 1.25 mm/octave of frequency. The present map, recorded tinder physiological conditions, differs from earlier maps determined with different methods. The simple logarithmic place-frequency relation found in the mouse indicates that mice are acoustic generalists rather than specialists. (c) 2004 Elsevier B.V. All rights reserved.
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