期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 161, 期 1-2, 页码 1-11出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2004.11.016
关键词
neurosphere; human; spinal cord; forebrain; MHC; co-stimulatory molecules
The ability to expand human neural precursor cells in vitro offers new possibilities for future cell therapies. However, concern over immunologically based rejection of in vitro-expanded human neural cells confounds their use as donor cells. Here, we demonstrate that the expression of human leukocyte antigen (HLA) class I and II molecules, but not the co-stimulatory proteins CD40, CD80 and CD86, substantially increase during expansion of neurospheres. Furthermore, peripheral lymphocytes were unresponsive when co-cultured with in vitro-expanded neural cells. Taken together, these results suggest a low immunogenicity of these cultured human neural cells despite HLA incompatibility and high HLA expression. (C) 2004 Elsevier B.V All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据