期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 129, 期 2, 页码 248-256出版社
WILEY
DOI: 10.1111/j.1365-2141.2005.05443.x
关键词
CXC-chemokines; CXCRs; multiple myeloma; plasma cells; tumour progression
类别
Bone marrow endothelial cells (EC) from patients with multiple myeloma (MM) Were found to express and secrete higher amounts of the CXC-chemokines CXCL8/interleukin (IL)-8, CXCL11/interferon-inducible T-cell alpha chemoattractant (I-TAC), CXCL12/stromal cell-derived factor (SDF)-1 alpha, and CCL2/monocyte chemotactic protein(MCP)-1 than EC from human umbilical vein (HUVEC), considered as a healthy counterpart. Paired plasma cells and several MM cell lines expressed cognate receptors of each chemokine to a variable extent. When cells were exposed to chemokines, CXCL8/IL-8 and CXCL12/SDF-1 alpha stimulated their proliferation and all chemokines stimulated cell chemotaxis. It is suggested that angiogenesis also favours MM progression through the release of CXC-chemokines.
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