期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 49, 期 4, 页码 1553-1555出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.49.4.1553-1555.2005
关键词
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The mechanisms by which rRNA mutations confer clindamycin resistance were examined in Mycobacterium smegmatis strains containing homogeneous populations of ribosomes with base substitutions at nucleotides A2058 and A2059. Computer graphic predictions based on structural studies correlate with the resistance phenotypes for six of seven strains with unique rRNA mutations.
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