期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 6, 期 4, 页码 345-351出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1620
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Iron-sulphur clusters are important cofactors for proteins that are involved in many cellular processes, including electron transport, enzymatic catalysis and regulation. The enzymes that catalyse the formation of iron-sulphur clusters are widely conserved from bacteria to humans. Recent studies in model systems and humans reveal that iron-sulphur proteins have important roles in mitochondrial iron homeostasis and in the pathogenesis of the human disease Friedreich ataxia.
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