期刊
BIOMATERIALS
卷 26, 期 12, 页码 1349-1357出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2004.04.044
关键词
hydroxyapatite; coating; osteoblast-like cells; sol-gel processing; plasma spraying
Sol gel processing was used to coat titanium substrates with hydroxyapatite (HA), TiO2, and poly(DL-lactic-glycolic acid). Coating surface characteristics were analyzed with XRD, EDS, AFM, SEM, and water contact angle measurements which indicated that the coatings had a high degree of crystallinity and good resistance to cracking. Coatings were also evaluated by cytocompatibility testing with osteoblast-like cells (or bone-forming cells). The cytocompatibility of the HA composite coatings prepared in the present in vitro study was compared to that of a traditional plasma-sprayed HA coating. Results showed that osteoblast-like cell adhesion was promoted on the novel HA sol-get coating compared to the traditional plasma-sprayed HA coating. In addition, hydrothermal treatment of the sol-gel coating improved osteoblast-like cell adhesion. Since osteoblast adhesion is a necessary prerequisite for subsequent formation of bone, these results provided evidence that hydrothermally sot-gel processed HA may improve bonding of titanium implants to juxtaposed bone and, thus, warrants further investigation. (C) 2004 Elsevier Ltd. All rights reserved.
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