期刊
AMERICAN JOURNAL OF KIDNEY DISEASES
卷 45, 期 4, 页码 758-761出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.ajkd.2005.01.001
关键词
pulmonary-renal syndrome; vasculitis; microscopic polyangiitis (MPA); antineutrophil cytoplasmic antibodies (ANCAs)
Despite clinical and experimental data suggesting a direct relationship between antineutrophil cytoplasmic antibodies (ANCAs) and disease activity in patients with microscopic polyanglitis (MPA), the causal relationship between perinuclear ANCAs specific for myeloperoxidase (MPO-ANCA) and disease manifestations has been controversial. We describe the case of a woman with a history of pulmonary-renal syndrome caused by MPA whose disease became clinically and serologically active during pregnancy. Forty-eight hours after delivery, the newborn developed pulmonary hemorrhage and abnormalities in renal function. The newborn's cord blood showed an immunoglobulin G MPO-ANCA level identical to that of the mother's serum, indicating passive transfer of the antibody to the neonate. Our findings represent the first human model supporting the interpretation that MPO-ANCAs were immunopathogenic. (c) 2005 by the National Kidney Foundation, Inc.
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