期刊
AMERICAN JOURNAL OF SURGERY
卷 189, 期 4, 页码 425-428出版社
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjsurg.2005.01.011
关键词
complicated skin and soft tissue infections; MRSA; linezolid; vancomycin
类别
Background: Resistant bacteria often complicate the management of skin and soft tissue infections of the lower extremities. This open-label study compared oral linezolid and intravenous vancomycin for management of complicated skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Methods: Patients aged 18 years or older with proven MRSA-related complicated skin and soft-tissue infections requiring surgical intervention were randomized to receive oral linezolid (n = 30) or intravenous vancomycin (n = 30) for 7 to 21 days. Clinical and microbiological outcomes, duration of hospitalization and drug treatment, and outpatient charges were determined. Results: Linezolid was associated with greater rates of clinical cure and improvement (P = .015), a 3-day shorter median length of stay (P = .003), and reduced outpatient charges (P <.001). Vancomycin therapy was associated with more treatment failures and subsequent lower-extremity amputations (P = .011). Conclusions: Clinical outcomes were significantly better with linezolid than with vancomycin. Additionally, linezolid was associated with reduced length of stay and outpatient charges. (c) 2005 Excerpta Medica Inc. All rights reserved.
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