期刊
ATHEROSCLEROSIS
卷 179, 期 2, 页码 387-393出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2004.10.032
关键词
apolipoproteins C; apolipoproteins E; hypertriglyceridemia; genetics; biochemical; genetics; genotype
资金
- NCRR NIH HHS [M01 RR 00645] Funding Source: Medline
- NICHD NIH HHS [R01 HD 32195] Funding Source: Medline
We examined the effect of APOCI-317insCGTT allele status (Hpal RFLR deletion [H I] and insertion [H2] alleles) on serum apolipoprotein (apo) CA level in 362 Hispanic children in the Columbia University BioMarkers Study. The H2 allele was present in 147 subjects (40.6%). Serum apoC-I was 20% lower in the presence of the H2 allele in APOE epsilon 3/epsilon 3 homozygotes (P=0.003) but did not differ by H2 status in epsilon 4 carriers. Insufficient numbers of epsilon 2 carriers (N=45) were present for analysis. In multivariate analysis in the epsilon 3/epsilon 3 context, after adjusting for potential covariate effects and familial aggregation, the mean effect of H2/* versus HIM I on apoC-I level, was estimated to be 2.15 +/- 10.55mg/dl (P < 0.0025). Plasma triglyceride level was weakly correlated with serum apoC-I level (Pearson's r=0.17, P < 0.001) but was highly correlated with serum apoC-III (Pearson's r=0.74, P < 0.0001). Nevertheless, presence of the H2 allele was not significantly associated with serum apoC-III level. Thus, the effect of APOC1 genotype on serum apoC-I level was not due to apoC-1 level serving as a surrogate for triglyceride level. The APOCI-317insCGTT allele is a commonly polymorphic genetic marker that is associated with serum apoC-I level in the APOE epsilon 3/epsilon 3 context. These findings suggest that the mechanism of the previously described association with plasma TG is, at least in part, related to the correlation of the polymorphism with the level of expression of apoC-1. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据