期刊
MICROBES AND INFECTION
卷 7, 期 4, 页码 760-766出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2005.01.013
关键词
Leishmania amazonensis; sand fly; saliva; protective immunity; Phlebotomus; Lutzomyia
资金
- NIAID NIH HHS [AI-20486] Funding Source: Medline
Immune response of BALB/c mice to the salivary antigens of sand flies was found to vary with different species used, i.e. Phlebotomus papatasi, Phlebotomus sergenti and Lutzomyia longipalpis. Exposure of mice to bites of these sand flies elicits production of antibodies, which are largely specific to different saliva antigens previously identified as unique to the respective fly species. When immunized intradermally (i.d.) with salivary gland lysates (SGL) of L. longipalpis, BALB/c mice developed partial protective immunity against challenges in the contralateral ears with Leishmania amazonensis plus the gland lysates. Preimmunization of these mice with the lysates from the other two species was ineffective, further indicative of the specificity of saliva-mediated immune response. The partial protective immunity observed is significant, although it is not as dramatic as reported previously in a different sand fly-mouse model. There is a correlation of this immunity with a lower number of mononuclear and polymorphonuclear phagocytes at the site of parasite inoculation. Vector species-specificity of this immunity implies its elicitation by unique saliva antigen-an issue which requires attention when designing saliva-based vaccines against leishmaniasis. (c) 2005 Elsevier SAS. All rights reserved.
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