期刊
MOLECULAR AND CELLULAR BIOLOGY
卷 25, 期 8, 页码 3109-3116出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.25.8.3109-3116.2005
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资金
- NCI NIH HHS [P30-CA16086, R01 CA081343, CA81343, P30 CA016086] Funding Source: Medline
- NIEHS NIH HHS [P30-ES10126, P30 ES010126] Funding Source: Medline
- NIGMS NIH HHS [GM32833, R01 GM032833, GM31082, R01 GM031082, R37 GM031082] Funding Source: Medline
The Timeless protein is essential for circadian rhythm in Drosophila. The Timeless orthologue in mice is essential for viability and appears to be required for the maintenance of a robust circadian rhythm as well. We have found that the human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.
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