期刊
NATURE IMMUNOLOGY
卷 6, 期 4, 页码 338-344出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1180
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- NIAID NIH HHS [R37AI51378] Funding Source: Medline
Mechanisms of immunosuppression by CD4(+)CD25(+) suppressor T cells have been addressed using many in vitro and in vivo conditions. However, those studies have not yielded a single mode of action. This review will discuss the mechanisms of suppression, which include the local secretion of cytokines such as TGF-beta and direct cell contact through binding of cell surface molecules such as CTLA-4 on suppressor T cells to CD80 and CD86 molecules on effector T cells. Suppression requires the appropriate colocalization of suppressor and effector T cells in different tissue and may involve the interference with T cell receptor signaling that triggers transcription factors important in regulating effector cell function.
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