期刊
SEMINARS IN ARTHRITIS AND RHEUMATISM
卷 34, 期 5, 页码 34-38出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.semarthrit.2005.01.009
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- NIAID NIH HHS [N01-AI45244, AI95383] Funding Source: Medline
Several studies show that the risk of granulomatous infections following therapy with the anti-tumor necrosis factor (TNF) antibody infliximab is higher than after treatment with the soluble TNFRp75 immunoglobulin fusion construct etanercept. Therefore, despite sharing a common target, it is possible that the actual mode of action of the 2 biologicals differs in vivo. TNF is known to participate in the induction and maintenance of protective granulomas at multiple steps, and evidence supporting a differential inhibition of TNF bioactivity and signaling by the 2 drugs is discussed. (c) 2005 Elsevier Inc. All rights reserved.
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